The MOUSE ANTI HUMAN SIGLEC-5/SIGLEC-14 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CD170, SIGLEC5, and SIGLECF. This antibody recognizes Human antigen. The MOUSE ANTI HUMAN SIGLEC-5/SIGLEC-14 Antibody has been validated for the following applications: ELISA, Flow Cytometry, Immunofluorescence, and Immunoprecipitation.
Description
MBS224725 recognises human Siglec-5 (Sialic acid-binding Ig-like lectin 5), otherwise known as CD170, a novel sialic-acid-binding Ig-like lectin, and member of the Ig superfamily, expressed by dendritic cells (DCs), activated macrophages, neutrophils, and cells of the monocyte/myeloid lineage. Clone 1A5, is one of several Siglec-5 antibodies which also recognises human Siglec-14 (Sialic acid-binding Ig-like lectin 14), see Angata, T. et al. for details. Siglec-14 shares an almost identical sequence with Siglec-5 within the first two Ig-like domains, indicating partial gene conversion between these two Siglecs, also evident in other primate species. Siglec-5 is highly related to the myelomonocytic-derived adhesion molecule CD33 (Siglec-3), and mediates sialic-acid dependent binding to cells, as well as acting as an inhibitory receptor in the down-regulation of cell activation. Structurally, Siglec-5 contains an immunoreceptor tyrosine-based inhibitor motif (ITIM), which plays a part in the modulation of cellular responses, and when phosphorylated, can bind to the SH2 domain of several SH2-containing phosphatases. Siglec-14 is a putative sialic-acid binding adhesion molecule, and member of the Ig superfamily, predominantly expressed in hematopoietic tissues, which has been shown to associate with the activating adapter protein DAP12. Clone 1A5 has been show to cross react with Chimpanzee, see Jaroenpool, J. et al. for details